Ducharme is a surname. Notable people with the surname include:
Annette Ducharme, Canadian musician and songwriter
Denis Ducharme (1955-), Canadian politician
Dominique Ducharme (1765–1853), French Canadian settler and fur trader
Gerry Ducharme (1939-), Canadian politician
Jean-Marie Ducharme (1723–1807), Fur trader and politician
Moira Leiper Ducharme, Canadian politician
Raymond Ducharme Morand (1887–1952), Canadian politician
Réjean Ducharme (1941-), Canadian novelist and playwright
Rick Ducharme (1948-), Canadian administrator
Romulus Ducharme (1886–1976), Canadian politician
Severin Ducharme (1866-19??), Canadian politician
Theresa Ducharme (1945–2004), Canadian activist
Todd Ducharme, Canadian judge
Yvan Ducharme (1937–2013), Canadian actor
Yves Ducharme (1958-), Canadian politician