Duane is a surname. Notable persons with that surname include:
Anthony Duane (1679–1747), Irish born American congressman, Mayor of New York City and judge
Diane Duane (born 1952), American science fiction and fantasy author
James Duane (1733–1797), American lawyer, jurist, and Revolutionary leader
James Duane (professor) (born 1959), American legal academic
James Chatham Duane (1824–1897), American engineering officer in the Union Army during the American Civil War
Michael Duane (1915–1997), Irish-born British progressive educationalist and headteacher
Thomas Duane (born 1955), American member of the New York State Senate
William Duane (physicist) (1872–1935), American physicist
William John Duane (1780–1865), Irish born American politician and lawyer
Thomas Sean Duane (born 1962), American artist, fashion designer and technologist
