Dreyfus is a surname. Notable people with the surname include:
Alfred Dreyfus (1859–1935), French Jewish military officer and focus of the Dreyfus affair
Auguste Dreyfus (1827–1897), French guano merchant, financier
Camille Dreyfus (1878–1956), Swiss chemist. He and his brother Henri Dreyfus invented Celanese, an acetate yarn.
Camille Ferdinand Dreyfus (1849–1915), French lawyer who was Senator for Seine-et-Oise from 1909 to 1915.
Charles Dreyfus (1848–1935), British-French Zionist and businessman
Édouard Dreyfus Gonzalez (1876–1941) French lawyer and composer as "Jean Dora".
Ferdinand-Camille Dreyfus (1851–1915), French journalist and politician
Francis Dreyfus (1940–2010), French record producer, father of Julie Dreyfus
George Dreyfus (born 1928), Australian composer, father of Mark Dreyfus
Gérard Louis-Dreyfus (1932-2016), French-American businessman (Louis Dreyfus Group), father of Julia Louis-Dreyfus, cousin of Robert Louis-Dreyfus
Robert Louis-Dreyfus (1946–2009), French businessman (Adidas-Salomon), cousin of Gérard Louis-Dreyfus
Harry Dreyfus (1891–1978), American businessman implicated in the Secret Court of 1920
Henri Dreyfus (1882–1944), Swiss chemist and co-inventor of Celanese
Hubert Dreyfus (born 1929), American philosopher (University of California, Berkeley), brother of Stuart Dreyfus
Huguette Dreyfus (1928-2016), French harpsichordist
Jack Dreyfus (1913–2009), American financier, founder of the Dreyfus Corporation
Jérôme Dreyfus (born 1971), French judoka
Julie Dreyfus (born 1966), French actress
Karen Dreyfus, American violist
Laurence Dreyfus (born 1952), American baroque music scholar and viol player
Lee S. Dreyfus (1926–2008), American politician, Governor of Wisconsin (1979–1983)
Mark Dreyfus (born 1956), Australian lawyer and politician, MP for Isaacs (2007–present), son of George Dreyfus
Max Dreyfus (1874–1964), German-born American music publisher
Pablo Dreyfus (1969/70–2009), Argentine arms controller
Philippe Dreyfus, French informatics pioneer
Pierre Dreyfus (1907–1994), French civil servant, politician and businessman (Renault)
René Dreyfus (1905–1993), French Grand Prix motor racing driver
Stuart Dreyfus, American academic, engineer and author (University of California, Berkeley), brother of Hubert Dreyfus
Tony Dreyfus (born 1939), French politician, Member of the National Assembly for Paris (1997–present)
Yves Dreyfus (born 1931), French Olympic fencer