Drexel is a surname and occasional given name. Notable people named Drexel include:
Anthony Drexel Duke, philanthropist, author and founder of Boys & Girls Harbor
Anthony Joseph Drexel (1826-1893), American banker, founder of Drexel, Morgan & Co.
Anthony Joseph Drexel Biddle, Sr. (1874–1948), American soldier, amateur boxer and writer
Anthony Joseph Drexel Biddle, Jr. (1897-1961), American diplomat and soldier
Constance Drexel (1894-1956), a naturalized American journalist, and Nazi broadcaster
Drexel Gomez (born 1937), Bahamian Anglican bishop
Elizabeth Wharton Drexel (1868-1944), American writer and socialite
Francis Anthony Drexel (1824-1885), American banker
Francis Martin Drexel (1792-1863), Austrian-American painter and banker, founder of Drexel & Co.
Hans Drexel (1919-1962), German World War 2 soldier
Ingrid Drexel (born 1993), Mexican road bicycle racer
Jeremias Drexel (1581-1638), German Jesuit and professor
John Drexel, American poet, critic, and editor
John Armstrong Drexel (1891-1958), American aviation pioneer
Joseph William Drexel (1833-1888), American banker, philanthropist and book collector
Katharine Drexel (1858–1955), American philanthropist, religious sister, and Roman Catholic saint
Ruth Drexel (1930-2009), German actress and director
Simone Drexel (born 1957), Swiss singer and songwriter
Wiltrud Drexel (born 1950), Austrian alpine skier
