Drescher is a surname. Notable people with the surname include:
Bill Drescher (1921–1968), American baseball playerChester Drescher (1982–2000), performing dog born in 1982 in QueensDick Drescher (born 1946), American discus throwerFran Drescher (born 1957), American film and television actress and comedianGary Drescher, scientist in the field of artificial intelligenceIsabel Drescher (born 1994), German figure skaterJack Drescher (born 1951), American psychiatrist and psychoanalystLudvig Drescher (1881–1917), Danish amateur football playerManuela Drescher, East German cross country skierOtto Drescher (1895–1944), highly decorated Generalleutnant in the Wehrmacht during World War IISeymour Drescher, American historian and a professorThomas Drescher (born 1978), German football player