Drayton is a surname. Notable people with the surname include:
Bill Drayton (born 1943), American social entrepreneur and environmentalist
Charley Drayton, American musician
Clay Drayton (born 1947), American songwriter and record producer
Dean Drayton (born 1941), Australian church leader
Jerome Drayton (born 1945), Canadian distance runner
John Drayton (1766–1822), Governor of South Carolina
Joy Drayton (1916–2012), New Zealand teacher and politician
Michael Drayton (1563–1631), English poet
Paul Drayton (athlete) (born 1939), American athlete, gold medal winner at the 1964 Summer Olympics
Paul Drayton (composer), English musician
Percival Drayton (1812–1865), United States Navy officer
Poppy Drayton (born 1991), English actress
Thomas Drayton (1809–1899), American Civil War Confederate general
William Drayton (1776–1846), American congressman
William Drayton, Sr. (1733–1790), American lawyer and judge
William Henry Drayton (1742–1779), American lawyer, South Carolina delegate to Continental Congress
William J. Drayton (born 1959), the real name of American rap artist Flavor Flav