EC number 5.3.3.8 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 62213-29-0 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a dodecenoyl-CoA isomerase (EC 5.3.3.8) is an enzyme that catalyzes the chemical reaction
(3Z)-dodec-3-enoyl-CoAHence, this enzyme has one substrate, (3Z)-dodec-3-enoyl-CoA, and one product, (2E)-dodec-2-enoyl-CoA.
This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is dodecenoyl-CoA (3Z)-(2E)-isomerase. Other names in common use include dodecenoyl-CoA Delta-isomerase, Delta3-cis-Delta2-trans-enoyl-CoA isomerase, acetylene-allene isomerase, dodecenoyl-CoA Delta-isomerase, and dodecenoyl-CoA Delta3-cis-Delta2-trans-isomerase. This enzyme participates in fatty acid metabolism.
Structural studies
As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 1HNO, 1HNU, 1K39, 1PJH, 1SG4, 1WDK, 1WDL, 1WDM, 1XX4, 2CQU, 2D3T, and 2F6Q.