Dobrescu is a Romanian surname. Notable people with the surname include:
Bogdan A. Dobrescu (born 1968), physicistConstantin Dobrescu-Argeș (1856-1903), politician and peasant activistDem I. Dobrescu (1869–1948), mayor of Bucharest (1929-1934) and political activistDimitrie Dobrescu (1852-1934), mayor of Bucharest (1911-1912), conservative politicianEmilian Dobrescu (born 1933), economistLiliana Dobrescu (born 1971), former Olympic medal winning swimmerLuminiţa Dobrescu, singerMihai Bogdan Dobrescu (born 1976), boxerMircea Dobrescu (born 1930), boxerNicolae Dobrescu (1874-1914), church historian