Dissanayake or Dissanayaka is a Sinhalese surname. It means area leader. Notable people with the surname include:
Anura Kumara Dissanayaka (born 1968), Sri Lankan politician
Berty Premalal Dissanayake (1954–2013), Sri Lankan politician
Cyril Dissanayake, Sri Lankan police officer
Duminda Dissanayake (born 1979), Sri Lankan politician
Ellen Dissanayake, American anthropologist
Gamini Dissanayake (1942–1994), Sri Lankan politician
Jayani Dissanayake, Sri Lankan politician
Jayasena Dissanayake, Sri Lankan politician
Kolitha Dissanayake, Sri Lankan cricketer
Lakdasa Dissanayake, Sri Lankan surgeon
Lalith Dissanayake, Sri Lankan politician
Mayantha Dissanayake (born 1980), Sri Lankan politician
Navin Dissanayake (born 1969), Sri Lankan politician
P. Weerakumara Dissanayake, Sri Lankan politician
Rohana Dissanayake, Sri Lankan politician
S. A. Dissanayake (1913–1982), Sri Lankan police officer
S. B. Dissanayake (born 1951), Sri Lankan politician
Salinda Dissanayake (born 1958), Sri Lankan politician
Sarath Dissanayake (born 1961), Sri Lankan Navy officer
Somaratne Dissanayake, Sri Lankan film director, screenwriter and producer
Sriyantha Dissanayake (born 1969), Sri Lankan sprinter
T. B. Dissanayake, Sri Lankan lawyer
T. D. S. A. Dissanayake, Sri Lankan diplomat and writer
W. M. P. B. Dissanayake (1927–2003), Sri Lankan politician
