Dissanayake or Dissanayaka is a Sinhalese surname. It means area leader. Notable people with the surname include:
Anura Kumara Dissanayaka (born 1968), Sri Lankan politicianBerty Premalal Dissanayake (1954–2013), Sri Lankan politicianCyril Dissanayake, Sri Lankan police officerDuminda Dissanayake (born 1979), Sri Lankan politicianEllen Dissanayake, American anthropologistGamini Dissanayake (1942–1994), Sri Lankan politicianJayani Dissanayake, Sri Lankan politicianJayasena Dissanayake, Sri Lankan politicianKolitha Dissanayake, Sri Lankan cricketerLakdasa Dissanayake, Sri Lankan surgeonLalith Dissanayake, Sri Lankan politicianMayantha Dissanayake (born 1980), Sri Lankan politicianNavin Dissanayake (born 1969), Sri Lankan politicianP. Weerakumara Dissanayake, Sri Lankan politicianRohana Dissanayake, Sri Lankan politicianS. A. Dissanayake (1913–1982), Sri Lankan police officerS. B. Dissanayake (born 1951), Sri Lankan politicianSalinda Dissanayake (born 1958), Sri Lankan politicianSarath Dissanayake (born 1961), Sri Lankan Navy officerSomaratne Dissanayake, Sri Lankan film director, screenwriter and producerSriyantha Dissanayake (born 1969), Sri Lankan sprinterT. B. Dissanayake, Sri Lankan lawyerT. D. S. A. Dissanayake, Sri Lankan diplomat and writerW. M. P. B. Dissanayake (1927–2003), Sri Lankan politician