Formula C8H9N1O4 | Molar mass 183.05 g/mol | |
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(S)-3,5-Dihydroxyphenylglycine or DHPG is a potent agonist of group I metabotropic glutamate receptors (mGluRs) mGluR1 and mGluR5.
DHPG was the first agonist shown to be selective for group I mGluRs. Agonist activity is found in only the (S)-isomer, and (S)-DHPG may be a partial agonist of group I mGluRs.
(S)-DHPG has been investigated for therapeutic effects in the treatment of neuronal injury (such as those associated with ischemia or hypoxia), cognitive enhancement, and Alzheimer's disease.
3,5-Dihydroxyphenylglycine can be isolated from the latex of Euphorbia helioscopia.
References
Dihydroxyphenylglycine Wikipedia(Text) CC BY-SA