Dihydropyrimidine dehydrogenase (NADP )

Updated on Oct 30, 2023

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EC number 1.3.1.2 IntEnz IntEnz view ExPASy NiceZyme view		CAS number 9029-01-0 BRENDA BRENDA entry KEGG KEGG entry

In enzymology, a dihydropyrimidine dehydrogenase (NADP+) (EC 1.3.1.2) is an enzyme that catalyzes the chemical reaction

5,6-dihydrouracil + NADP⁺ ⇌ uracil + NADPH + H⁺

Thus, the two substrates of this enzyme are 5,6-dihydrouracil and NADP⁺, whereas its 3 products are uracil, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor.

The systematic name of this enzyme class is 5,6-dihydrouracil:NADP+ 5-oxidoreductase.
Other names in common use include:

dihydrothymine dehydrogenase

dihydrouracil dehydrogenase (NADP+)

4,5-dihydrothymine: oxidoreductase

DPD

DHPDH

dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide, phosphate)

DHU dehydrogenase

hydropyrimidine dehydrogenase

dihydropyrimidine dehydrogenase (NADP+)

This enzyme participates in 3 metabolic pathways: pyrimidine metabolism, beta-alanine metabolism, and pantothenate and coa biosynthesis.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1GT8, 1GTE, 1GTH, 1H7W, and 1H7X.

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