Symbol DPYD HUGO 3012 RefSeq NM_000110 | Entrez 1806 OMIM 274270 EC number 1.3.1.2 | |
Dihydropyrimidine dehydrogenase (DPD) is an enzyme that is involved in pyrimidine degradation. It is the initial and rate-limiting step in pyrimidine catabolism. It catalyzes the reduction of uracil and thymine. It is also involved in the degradation of the chemotherapeutic drugs 5-fluorouracil and Tegafur-uracil.
References
Dihydropyrimidine dehydrogenase Wikipedia(Text) CC BY-SA