Diethyl 2 methyl 3 oxosuccinate reductase

In enzymology, a diethyl 2-methyl-3-oxosuccinate reductase (EC 1.1.1.229) is an enzyme that catalyzes the chemical reaction

diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP⁺ ⇌ diethyl 2-methyl-3-oxosuccinate + NADPH + H⁺

Thus, the two substrates of this enzyme are diethyl (2R,3R)-2-methyl-3-hydroxysuccinate and NADP⁺, whereas its 3 products are diethyl 2-methyl-3-oxosuccinate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is diethyl-(2R,3R)-2-methyl-3-hydroxysuccinate:NADP⁺ 3-oxidoreductase.