ATC code None CAS Number 67165-56-4 ChemSpider 62103 Molar mass 322.229 g/mol | Legal status In general: legal PubChem CID 68871 UNII 09HKW863J6 | |
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What does diclofensine mean
Diclofensine (Ro 8-4650) was developed by Hoffmann-La Roche in the 1970s in the search for a new antidepressant. It was found that the (S)-isomer was responsible for activity. Is a stimulant drug which acts as a triple monoamine reuptake inhibitor, primarily inhibiting the reuptake of dopamine and norepinephrine, with affinities (Ki) of 16.8 nM, 15.7 nM, and 51 nM for DAT, NET, and SERT (dopamine, norepinephrine and serotonin transporters), respectively. It was found to be an effective antidepressant in human trials, with relatively few side effects, but was ultimately dropped from clinical development, possibly due to concerns about its abuse potential.
Diclofensine is chemically a tetrahydroisoquinoline (THIQ) derivative, as is nomifensine.