ATC code none PubChem CID 127024 Formula C15H17Cl2NO2 Molar mass 314.207 g/mol | CAS Number 146725-34-0 ChemSpider 112783 3D model (Jmol) Interactive image | |
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Dichloropane ((−)-2β-Carbomethoxy-3β-(3,4-dichlorophenyl)tropane, RTI-111, O-401) is a stimulant of the phenyltropane class that acts as a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) with IC50 values of 3.13, 0.79 and 18 nM, respectively. In animal studies, dichloropane had a slower onset and longer duration of action compared to cocaine.
Methylecgonidine as the direct precursor to this compound.
Trans -CO2Me group
The thermodynamic isomer with a trans -CO2Me group is still active. This isomer was used by Neurosearch to make three different phenyltropanes which were tested in clinical trials.
References
Dichloropane Wikipedia(Text) CC BY-SA