EC number 4.1.1.20 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 9024-75-3 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a diaminopimelate decarboxylase (EC 4.1.1.20) is an enzyme that catalyzes the chemical reaction
meso-2,6-diaminoheptanedioateHence, this enzyme has one substrate, meso-2,6-diaminoheptanedioate, and two products, L-lysine and CO2.
This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is meso-2,6-diaminoheptanedioate carboxy-lyase (L-lysine-forming). Other names in common use include diaminopimelic acid decarboxylase, meso-diaminopimelate decarboxylase, DAP-decarboxylase, and meso-2,6-diaminoheptanedioate carboxy-lyase. This enzyme participates in lysine biosynthesis. It employs one cofactor, pyridoxal phosphate.
Structural studies
As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1HKV, 1HKW, 1KNW, 1KO0, 1TUF, 1TWI, 2O0T, and 2P3E.