Diadenosine hexaphosphate hydrolase (AMP forming)

Updated on Dec 20, 2024

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EC number 3.6.1.60 BRENDA BRENDA entry KEGG KEGG entry		IntEnz IntEnz view ExPASy NiceZyme view MetaCyc metabolic pathway

Diadenosine hexaphosphate hydrolase (AMP-forming) (EC 3.6.1.60, hAps1, NUDT11 (gene), hAps2, NUDT10 (gene)) is an enzyme with systematic name P1,P6-bis(5'-adenosyl)hexaphosphate nucleotidohydrolase (AMP-forming). This enzyme catalyses the following chemical reaction

(1) P1,P6-bis(5'-adenosyl)hexaphosphate + H₂O ⇌ adenosine 5'-pentaphosphate + AMP(2) P1,P5-bis(5'-adenosyl)pentaphosphate + H₂O ⇌ adenosine 5'-tetraphosphate + AMP

A divalent cation is essential for activity.

References

Diadenosine hexaphosphate hydrolase (AMP-forming) Wikipedia

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