di Pietro is an Italian surname. Notable people with the surname include:
Angelo Di Pietro (1828–1914), Italian cardinal
Angelo Di Pietro (inventor) (born 1950), Italian engine designer
Anthony Di Pietro (born 1969), Italian Australian businessman
Antonio Di Pietro (born 1950), Italian politician
Bruno Barros di Pietro (born 1982), Brazilian football defender
Camillo di Pietro (1806–1884), Italian cardinal
Giovani Battista di Pietro di Stefano Volponi (16th century), Italian painter
Guido di Pietro (circa 1395–1455), Italian painter
Innocenzo di Pietro Francucci da Imola (circa 1494–1550), Italian painter
Michele di Pietro (1747–1821), Italian cardinal
Niccolò di Pietro Gerini (circa 1340–1414), Italian painter
Nicola di Pietro (14th century), Italian painter
Rick DiPietro, American ice hockey player
Rocco Di Pietro (born 1949), Italian-American composer
Sano di Pietro (1406–1481), Italian painter
