Desiderio is both a surname and a given name in Italian, Spanish and Portuguese (Desidério), derived from the Latin Desiderius. Notable people with the name include:
Surname:
Monsù Desiderio (1593–1620), French painter
Reginald B. Desiderio (1918–1950), soldier in the United States Army
Robert Desiderio (born 1951), American actor
Vincent Desiderio (born 1955), American realist painter
Given name:
Desiderio Costa (21st century), Angolan politician
Desiderio da Settignano (circa 1430–1464), Italian sculptor
Desi Arnaz (1917–1986), Cuban-born American entertainer
