Descalzi is an Italian surname. It is pronounced [desˈkalt͡si]. Notable people with the surname include:
Carlos Herrera Descalzi (born 1945), Peruvian engineer and politician
Cayetano Descalzi (born Gaetano Descalzi) (1809–1886), Italian painter and engraver active in Argentina
Claudio Descalzi (born 1955), Italian businessman in the energy sector
Giuseppe Gaetano Descalzi (1767-1855), Genoese furniture maker
Nicolás Descalzi, Italian explorer active in Argentina
Leonardo Stagg Descalzi, Ecuadorian economist and politician.
Places
Nicolás Descalzi, a station of the Buenos Aires Premetro