Derr is a surname. Notable people with the surname include:
Allen Derr (1928–2013), American lawyerA. M. Derr (1903–1970), American politician from IdahoHelen Derr (1918–2011), American journalistJohn W. Derr (born 1941), former Maryland State SenatorKenneth T. Derr, American businessmanMark Derr, American authorZac Derr, American football placekickerRichard Derr (1918–1992), American film and television actorJill Mulvay Derr (born 1948), American history professorManuela Derr (born 1971), retired East German sprinter