EC number 4.1.2.4 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 9026-97-5 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a deoxyribose-phosphate aldolase (EC 4.1.2.4) is an enzyme that catalyzes the chemical reaction
2-deoxy-D-ribose 5-phosphateHence, this enzyme has one substrate, 2-deoxy-D-ribose 5-phosphate, and two products, D-glyceraldehyde 3-phosphate and acetaldehyde.
This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase (D-glyceraldehyde-3-phosphate-forming). Other names in common use include phosphodeoxyriboaldolase, deoxyriboaldolase, deoxyribose-5-phosphate aldolase, 2-deoxyribose-5-phosphate aldolase, and 2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase. This enzyme participates in pentose phosphate pathway.
Structural studies
As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes 1JCJ, 1JCL, 1KTN, 1MZH, 1N7K, 1O0Y, 1P1X, 1UB3, 1VCV, and 2A4A.