EC number 4.1.99.3 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 37290-70-3 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a deoxyribodipyrimidine photo-lyase (EC 4.1.99.3) is an enzyme that catalyzes the chemical reaction
Hence, this enzyme has one substrate, cyclobutadipyrimidine (in DNA), and one product, pyrimidine residues (in DNA).
This enzyme belongs to the family of lyases, specifically in the "catch-all" class of carbon-carbon lyases. The systematic name of this enzyme class is deoxyribocyclobutadipyrimidine pyrimidine-lyase. Other names in common use include photoreactivating enzyme, DNA photolyase, DNA-photoreactivating enzyme, DNA cyclobutane dipyrimidine photolyase, DNA photolyase, deoxyribonucleic photolyase, deoxyribodipyrimidine photolyase, photolyase, PRE, PhrB photolyase, deoxyribonucleic cyclobutane dipyrimidine photolyase, phr A photolyase, dipyrimidine photolyase (photosensitive), and deoxyribonucleate pyrimidine dimer lyase (photosensitive). It has 2 cofactors: FAD, and 5,10-Methenyltetrahydrofolate.
Structural studies
As of late 2007, 14 structures have been solved for this class of enzymes, with PDB accession codes 1DNP, 1IQR, 1IQU, 1OWL, 1OWM, 1OWN, 1OWO, 1OWP, 1QNF, 1TEZ, 2E0I, 2J07, 2J08, and 2J09.