EC number 2.7.1.145 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 52227-81-3 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a deoxynucleoside kinase (EC 2.7.1.145) is an enzyme that catalyzes the chemical reaction
ATP + 2'-deoxynucleosideThus, the two substrates of this enzyme are ATP and 2'-deoxynucleoside, whereas its two products are ADP and 2'-deoxynucleoside 5'-phosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:deoxynucleoside 5'-phosphotransferase. Other names in common use include multispecific deoxynucleoside kinase, ms-dNK, multisubstrate deoxyribonucleoside kinase, multifunctional deoxynucleoside kinase, D. melanogaster deoxynucleoside kinase, and Dm-dNK.
Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1OE0, 1OT3, 1ZM7, 1ZMX, and 2JCS.