Denis is a surname. Notable people with the surname include:
Denis (harpsichord makers) an influential family of Parisian harpsichord makers in the 16th and 17th centuries
Armand Denis (1896–1971), Belgian-born wildlife film-maker
Azellus Denis (1907–1991), Canadian politician
Claire Denis (born 1946), French film director
Germán Denis (born 1981), Argentine footballer
Harry Dénis (1896–1971), Dutch football player
Jonathan Denis (born 195), Canadian politician
Joseph Denis (1657–1736), Canadian priest
Léon Denis (1846–1927), spiritist philosopher
Marc Denis (born 1977), Canadian former ice hockey player
Marilyn Denis (born 1958), Canadian broadcaster
Maurice Denis (1870–1943), French painter
Michael Denis (1729–1800), Austrian poet and entomologist
Michaela Denis (1914–2003), wildlife documentary film-maker and presenter
Mo Denis (born 1961), American politician
Neil Denis (born 1987), Canadian actor
Sir Peter Denis, 1st Baronet (1713–1778), English officer and Member of Parliament
Ruth St. Denis (1879–1968), dancer and choreographer
Sergio Denis (born 1949), Argentine singer
Willey Glover Denis (1879–1929), American biochemist and physiologist
