Delta8 fatty acid desaturase

Delta8-fatty-acid desaturase (EC 1.14.19.4, Delta8-sphingolipid desaturase, EFD1, BoDES8, SLD, Delta8 fatty acid desaturase, Delta8-desaturase) is an enzyme with systematic name phytosphinganine,hydrogen donor:oxygen Delta8-oxidoreductase. This enzyme catalyses the following chemical reaction

phytosphinganine + reduced acceptor + O₂ ⇌ Delta8-phytosphingenine + acceptor + 2 H₂O

This enzyme, which has been found mainly in plants, introduces a double bond at Delta8 of C18 and C20 fatty acids.