Delta24 sterol reductase

In enzymology, a Delta24-sterol reductase (EC 1.3.1.72) is an enzyme that catalyzes the chemical reaction

5alpha-cholest-7-en-3beta-ol + NADP⁺ ⇌ 5alpha-cholesta-7,24-dien-3beta-ol + NADPH + H⁺

Thus, the two substrates of this enzyme are 5alpha-cholest-7-en-3beta-ol and NADP⁺, whereas its 3 products are 5alpha-cholesta-7,24-dien-3beta-ol, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is sterol:NADP+ Delta24-oxidoreductase. This enzyme is also called lanosterol Delta24-reductase. This enzyme participates in biosynthesis of steroids.