Degen is a surname. Notable people with the surname include:
Carl Ferdinand Degen (born 1766), Danish mathematician
Wilhelm Degen III (born 1964), German engineer
Philipp Degen (born 1983), Swiss footballer
Bruce Degen (born 1945), American author and illustrator
David Degen (born 1983), Swiss footballer
Paul Degen (1941–2007), Swiss artist
Silvije Degen (born 1942), Croatian politician
Kurt Degen, movie poster artist
Árpád Degen, Hungarian biologist and botanist
Bob Degen (born 1944), American jazz pianist
Jürgen Degen (born 1967), German footballer
