The name Defreine is of Norman Irish origin. There are many anglicised versions of the name - Frayne, Frenes, Freyne, DeFrayne, Franey, Freaney, Freeney, Frain, ffrench, Ffrench, French and possibly some more. All these names are the same and have been used, changed and interchanged over the years. All are derivatives of the same name “DeFreine”.
The DeFreines, the ffrenches, and the Frenches, who were of noble blood, came to Ireland with Strongbow during the Norman Invasion of Ireland from 1169 to 1172AD. There were and still are two or three families of Irish peers who carry the names DeFréine, ffrench, and French. As Anglo-Normans the French family became one of the 14 Tribes of Galway, helping to found the town in 1425AD, fortifying it to keep the locals out.
In Wexford the name Franey is common, In Wicklow Freeney / Freney is common and in the Connaught area (Sligo/Galway) Frain, Freine are common. The name is from the French word Frêne which means a wooded place with ash trees indicating that ancestors of that family came from an area noted for its forests. Some sources can even trace the name back to Roman times.