Defoe is a surname. Notable people with the surname include:
Annette DeFoe (1890–1960), American silent film actress
Daniel Defoe (c. 1659 to 1661–1731), English trader, writer, journalist and pamphleteer best known for writing Robinson Crusoe
Gideon Defoe (born 1975), author of Pirates!
Jermain Defoe (born 1982), English footballer who plays for Sunderland A.F.C.