DeWeese is a surname. Notable people with the surname include:
Bill DeWeese (born 1950), American politicianBob DeWeese (born 1934), American politicianBob DeWeese (basketball) (1915–1991), American basketball playerDevin Deweese (1835–1906), American historianEbby DeWeese (1904–1942), American football playerGene DeWeese (1934–2012), American writerGennie DeWeese (1921–2007), American painterJohn T. Deweese (1835–1906), American politicianMary Ann DeWeese (1913–1993), American designer