DeFeo is a surname. Notable people with the surname include:
Jay DeFeo (1929–1989), American artist
Massimo De Feo (born 1960), general authority of The Church of Jesus Christ of Latter-day Saints
Peter DeFeo (1902–1993), American mobster
Ronald DeFeo Jr. (born 1951), American mass murderer
Ubi de Feo (born 1974), Italian educator
Vincenzo De Feo (1876–1955), Italian Admiral