De la Rue, De La Rue or Delarue is a surname. Notable people with the surname include:
Charles de la Rue (1643-1725), noted orator of the Society of Jesus in France, poet and professor
Edgar Aubert de la Rüe (1901-1991), French geographer, geologist, traveller and photographer
Gervais de La Rue (1751-1835), French historical investigator, once regarded as an authorities on Norman and Anglo-Norman literature
Hippolyte De La Rue (1891-1977), Royal Australian Air Force air commodore
Jean-Luc Delarue (1964-2012), French French television presenter and producer
Lucie Delarue-Mardrus (1874–1945), French journalist, poet, novelist, sculptor, historian and designer
Maurice Delarue (1919–2013), French journalist
Paul-Henri de Le Rue (born 1984), French snowboarder, 2006 Olympic bronze medalist
Pierre de la Rue (c. 1452-1518), Franco-Flemish composer and singer
Thomas de la Rue (1793–1866), printer from Guernsey
Warren De la Rue (1815-1889), British astronomer and chemist
De La Rue baronets, various baronets with the surname
