De la Cruz is a Spanish surname meaning "Of the Cross". Notable people with the surname include:
Bethania de la Cruz (born 1987), Dominican Republic volleyball player
Cacho de la Cruz (born 1937), Argentine-Uruguayan entertainer
Carlos de la Cruz, chairman of CC1 Companies
Eulogio de la Cruz (born 1984), baseball player
Jerry De La Cruz (born 1948), an American artist
José María de la Cruz (1799–1875), a Chilean general and politician
José de la Cruz (1746–1829), a Filipino writer more popularly known as Huseng Sisiw
Juan de la Cruz (1542–91), Spanish friar and poet
Juana Inés de la Cruz (1648–1695), a scholar, poet and nun
Magdalena de la Cruz (1487–1560), Spanish Franciscan nun of Cordova
Melissa de la Cruz (born 1971), an American author
Oswaldo de la Cruz, a Peruvian politician
Ramón de la Cruz (1731–1794), a Spanish neoclassical dramatist
Tommy de la Cruz (1911–1958), a Major League Baseball pitcher
Ulises de la Cruz (born 1974), an Ecuadorian footballer
Veronica De La Cruz (born 1980), a Filipino-American television anchor
Fictional characters:
Cruz de la Cruz, a central character in John H. Ritter's baseball novel and his family's verisimilitudinous Web site
Music
De La Cruz, an 80's influenced hard rock band from Australia, who made their debut in 2013 with the album Street Level
