de la Croix is a French surname meaning "of the Cross". Notable people with the surname include:
Charles de la Croix (1792–1869), Flemish Roman Catholic missionaryCharles Eugène Gabriel de La Croix (1727–1801), French marshalÉtienne de la Croix (1579–1643), French Jesuit, missionary and writerFélix du Temple de la Croix (1823–1890), French naval officer and inventorFrançois Pétis de la Croix (1653–1713), French orientalistJean Louis de la Croix, French archerRaven De La Croix (born 1947), American actressSt. Sukie de la Croix (born 1951), American writer