de la Croix is a French surname meaning "of the Cross". Notable people with the surname include:
Charles de la Croix (1792–1869), Flemish Roman Catholic missionary
Charles Eugène Gabriel de La Croix (1727–1801), French marshal
Étienne de la Croix (1579–1643), French Jesuit, missionary and writer
Félix du Temple de la Croix (1823–1890), French naval officer and inventor
François Pétis de la Croix (1653–1713), French orientalist
Jean Louis de la Croix, French archer
Raven De La Croix (born 1947), American actress
St. Sukie de la Croix (born 1951), American writer