de Villiers is a common French and Afrikaans surname. It may refer to:
AB de Villiers, a current South African international cricketer
De Villiers Graaff, a former South African politician
CJ de Villiers, a former South African cricketer
Fanie de Villiers, a former South African cricketer
Gerard de Villiers, a French writer of spy stories
Giniel de Villiers, a South African racing driver
Jean de Villiers, a current South African international rugby union player
Juan de Villiers, a former South African cricketer
Marthinus Lourens de Villiers (1885 - 1977), a South African musician and composer who wrote the music for Die Stem van Suid-Afrika
Nannie de Villiers, a South African tennis player
Peter de Villiers, a South African rugby union coach named in 2008 as the head coach of the country's national team, the Springboks
Philippe de Villiers, a French politician
Pieter de Villiers, a South African hurdler
Pieter de Villiers, a South Africa-born French international rugby union player
