De Rossi is an Italian surname, and may refer to:
Alessandra De Rossi, Philippine actress
Assunta De Rossi, Philippine actress
Azariah dei Rossi, an Italian-Jewish physician and scholar
Bernardo de Rossi, Italian theologian and historian
Bernardo de' Rossi, Italian bishop
Daniele De Rossi, Italian footballer
Fabrizio De Rossi, a fictional character in the 1997 film Titanic
Giovan Antonio de' Rossi, (1616–1695), Italian architect of the Baroque
Giovanni Battista de Rossi, 19th-century Italian archaeologist
Giovanni Bernardo De Rossi, 19th-century Italian Christian Hebraist
Mattia de Rossi, (1637–1695), Italian architect of the Baroque
Properzia de' Rossi, Italian Renaissance sculptor
Portia de Rossi, Australian actress
Saint Giovanni Battista de Rossi, 18th-century Roman priest
