De Niro is a surname. Notable people with the surname include:
Drena De Niro (born 1967), American actress and film producer
Grace Hightower De Niro (born 1955), American philanthropist, socialite, actress, and singer
Robert De Niro, Sr. (1922–1993), American abstract expressionist painter
Robert De Niro (born 1943), American actor, director and producer
Virginia De Niro alias Virginia Admiral (1915–2000), American painter and poet