De Groote is a Dutch surname meaning "the big one". It is most common in Flanders and sometimes is concatenated as DeGroote or Degroote. People with this name include:
Jan de Groote (1911–1989), Dutch farmer and politician
Koenraad Degroote (born 1959), Belgian politician
Melvin De Groote (1895–1963), American chemist and inventor with 925 patents
Michel De Groote (born 1955), Belgian football defender
Michael DeGroote (born 1933), Canadian businessman and philanthropist
Patrick De Groote (born 1958), Belgian politician
fr:Paul De Groote (1905–1997), Belgian government minister
Steven De Groote (1953–1989), South African classical pianist
Thierry De Groote (born 1975), Belgian road bicycle racer
Wouter Degroote (born 1978), Belgian footballer
