De Clercq or de Clercq is a surname of Dutch origin. People with the name include:
Andrew DeClercq (born 1973), American basketball player
Bart De Clercq (born 1986), Belgian professional bicycle road racer
Daniël de Clercq (1854–1931), Dutch socialist and vegetarian activist
Erik De Clercq (born 1941), Belgian physician and biologist
Hans De Clercq (born 1969), former Belgian racing cyclist
Jean De Clercq (1905-1984), Belgian footballer
Jean-Christophe De Clercq (born 1966), French artist
Lucas de Clercq (1603–1652), Dutch cloth merchant, subject of painter Frans Hals
Mario De Clercq (born 1966), Belgian professional bicycle racer
Mathias De Clercq (born 1981), Belgian politician
Peter de Clercq (born 1959), Dutch diplomat
Peter De Clercq (born 1966), Belgian professional bicycle road racer
René de Clercq (1877–1932), Flemish-Dutch political activist, writer, poet, and composer
Staf De Clercq (1884–1942), Flemish Nazi collaborator and Flemish nationalist
Willem de Clercq (1795–1844), Dutch poet and leader of the Protestant Revival in the Netherlands
Willy De Clercq (1927–2011), Belgian politician and government minister
