De Clercq or de Clercq is a surname of Dutch origin. People with the name include:
Andrew DeClercq (born 1973), American basketball playerBart De Clercq (born 1986), Belgian professional bicycle road racerDaniël de Clercq (1854–1931), Dutch socialist and vegetarian activistErik De Clercq (born 1941), Belgian physician and biologistHans De Clercq (born 1969), former Belgian racing cyclistJean De Clercq (1905-1984), Belgian footballerJean-Christophe De Clercq (born 1966), French artistLucas de Clercq (1603–1652), Dutch cloth merchant, subject of painter Frans HalsMario De Clercq (born 1966), Belgian professional bicycle racerMathias De Clercq (born 1981), Belgian politicianPeter de Clercq (born 1959), Dutch diplomatPeter De Clercq (born 1966), Belgian professional bicycle road racerRené de Clercq (1877–1932), Flemish-Dutch political activist, writer, poet, and composerStaf De Clercq (1884–1942), Flemish Nazi collaborator and Flemish nationalistWillem de Clercq (1795–1844), Dutch poet and leader of the Protestant Revival in the NetherlandsWilly De Clercq (1927–2011), Belgian politician and government minister