De Boer, de Boer, and variants thereof, are Dutch surnames, deriving from the Dutch word for "farmer", boer. Notable people with the surname include:
Ad de Boer, Dutch politician and journalist
Aeint Herman De Boer, was the owner of Hotel de Boer (now Inna Dharma Deli Hotel) in Medan, Dutch East Indies
Ale de Boer (born 1987), Dutch footballer
Arthur DeBoer, American doctor
Betty de Boer, Dutch politician
Brent De Boer, drummer and backup vocalist with The Dandy Warhols
Frank de Boer (born 1970), Dutch football manager
Hannes de Boer, Dutch athlete
Harry DeBoer, American labor activist
Herman Pieter de Boer (1928–2014), Dutch writer, journalist and lyricist
Jan de Boer (gymnast) (1859-1941), Dutch gymnast
Jan de Boer (footballer) (1898-1988), Dutch association footballer
Jan de Boer (physicist), Dutch physicist
Jan Hendrik de Boer, Dutch scientist
Jelle Taeke de Boer (1908–1970), Dutch art collector
Johanna de Boer, Dutch fencer
John M. de Boer,(born 1966) U.S. Engineer
Johannes de Boer, German soldier
Kalen DeBoer, American footballer
Klaas de Boer, U.S. footballer
Lieuwe de Boer, Dutch speed skater
Margreeth de Boer, Dutch politician
Matt de Boer, Australian rules footballer
Mickey de Boer, Dutch international cricketer
Mieke de Boer, Dutch darts player
Nicole de Boer (born 1970), Canadian actress
Peter DeBoer, Canadian hockey player
Remmelt de Boer, Dutch educator and politician
René de Boer (born 1945), Dutch sculptor
Roelf de Boer, Dutch politician
Ronald de Boer (born 1970), Dutch football midfielder
Saco Rienk DeBoer, Dutch architect
Ted De Boer (1921–2004), the Founder of the National Inventors Foundation
Ted de Boer (born 1943), Dutch law scholar
Tobias de Boer (1930–2016), Dutch scientist
Wubbo de Boer, Dutch civil servant
Yoann de Boer (born 1982), Dutch football midfielder
Yvo de Boer, the current Executive Secretary of the United Nations Framework Convention on Climate Change