de Bie is a surname of Dutch origin. People with the name include:
Cornelis de Bie (1627–1715), Flemish rhetorician, poet, and juristDanny De Bie (born 1960), Belgian cyclocross racerJean De Bie (1892–1961), Belgian professional football playerMark De Bie (born 1939), Belgian television writerSilvy De Bie (born 1981), Belgian dance vocalistWim de Bie (born 1939), Dutch comedianHalf of the Dutch comedy duo Van Kooten en De BieWouly de Bie (born 1958), Dutch Olympic water polo player