de Bie is a surname of Dutch origin. People with the name include:
Cornelis de Bie (1627–1715), Flemish rhetorician, poet, and jurist
Danny De Bie (born 1960), Belgian cyclocross racer
Jean De Bie (1892–1961), Belgian professional football player
Mark De Bie (born 1939), Belgian television writer
Silvy De Bie (born 1981), Belgian dance vocalist
Wim de Bie (born 1939), Dutch comedian
Half of the Dutch comedy duo Van Kooten en De Bie
Wouly de Bie (born 1958), Dutch Olympic water polo player
