De Angelis or de Angelis is a surname of Italian origin. Notable people with the surname include:
Alberto de Angelis (1885–after 1926), Italian writer and biographer
Aldo DeAngelis (1931-2004), American politician
Alex de Angelis (born 1984), Sammarinese Grand Prix motorcycle road racer
April De Angelis (contemporary), British dramatist and playwright
Catherine D. DeAngelis, MD, editor of the Journal of the American Medical Association
Elio de Angelis (1958–1986), Italian Formula One race car driver
Enrico De Angelis (fl. 1940s), Italian singer
Filippo de Angelis (1792–1877), Italian Roman Catholic cardinal
Francesco De Angelis (musician) (born 1971), Italian classical violinist
Francesco de Angelis (b. 1960), Italian world championship sailboat racer
Frankie DeAngelis (born 1986), Canadian professional ice hockey defenceman
Gianluca De Angelis (footballer born 1967) Italian footballer actives in 1985-2005, Serie B, C1 & C2 players
Gianluca De Angelis (footballer born 1981) Italian footballer in 2000s to early 2010s, Serie C1 & C2 players
Guido & Maurizio De Angelis (contemporary), Italian composers and singers
Jerome de Angelis (1567–1623), Italian Jesuit missionary to Japan; executed by fire
Maximilian de Angelis (1889–1974), German general officer during World War II; POW 1945–55
Milo de Angelis (born 1951), Italian poet
Nazzareno De Angelis (1881–1962), Italian operatic bass singer
Perry DeAngelis (1964-2007), co-founder and executive director of NESS, co-founder of The Skeptics' Guide to the Universe
Richard De Angelis (1932 – 2005), American actor and comedian
Roberto De Angelis (born 1959), Italian comic book artist
Rosemary De Angelis (born 1933), American stage, film, and television actress
Sandro DeAngelis (born 1981), Canadian gridiron football placekicker
Tino De Angelis (born 1915), American confidence man and commodities trader
Wilma De Angelis (born 1931), Italian popular singer
