De Angelis or de Angelis is a surname of Italian origin. Notable people with the surname include:
Alberto de Angelis (1885–after 1926), Italian writer and biographerAldo DeAngelis (1931-2004), American politicianAlex de Angelis (born 1984), Sammarinese Grand Prix motorcycle road racerApril De Angelis (contemporary), British dramatist and playwrightCatherine D. DeAngelis, MD, editor of the Journal of the American Medical AssociationElio de Angelis (1958–1986), Italian Formula One race car driverEnrico De Angelis (fl. 1940s), Italian singerFilippo de Angelis (1792–1877), Italian Roman Catholic cardinalFrancesco De Angelis (musician) (born 1971), Italian classical violinistFrancesco de Angelis (b. 1960), Italian world championship sailboat racerFrankie DeAngelis (born 1986), Canadian professional ice hockey defencemanGianluca De Angelis (footballer born 1967) Italian footballer actives in 1985-2005, Serie B, C1 & C2 playersGianluca De Angelis (footballer born 1981) Italian footballer in 2000s to early 2010s, Serie C1 & C2 playersGuido & Maurizio De Angelis (contemporary), Italian composers and singersJerome de Angelis (1567–1623), Italian Jesuit missionary to Japan; executed by fireMaximilian de Angelis (1889–1974), German general officer during World War II; POW 1945–55Milo de Angelis (born 1951), Italian poetNazzareno De Angelis (1881–1962), Italian operatic bass singerPerry DeAngelis (1964-2007), co-founder and executive director of NESS, co-founder of The Skeptics' Guide to the UniverseRichard De Angelis (1932 – 2005), American actor and comedianRoberto De Angelis (born 1959), Italian comic book artistRosemary De Angelis (born 1933), American stage, film, and television actressSandro DeAngelis (born 1981), Canadian gridiron football placekickerTino De Angelis (born 1915), American confidence man and commodities traderWilma De Angelis (born 1931), Italian popular singer