Harman Patil

Dasotraline

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CAS Number  675126-05-3
ChemSpider  8123611
ChEMBL  CHEMBL3301595
PubChem CID  9947999
UNII  4D28EY0L5T
Formula  C16H15Cl2N
Dasotraline

Dasotraline (INN) (former developmental code name SEP-225,289) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) that is under development by Sunovion for clinical use. The drug is no longer being developed for major depressive disorder (MDD), but is still under investigation for the treatment of attention-deficit hyperactivity disorder (ADHD) and eating disorders. Structurally, dasotraline is a stereoisomer of desmethylsertraline, which is an active metabolite of the marketed selective serotonin reuptake inhibitor (SSRI) antidepressant sertraline (Zoloft) and an SNDRI similarly.

Side Effects

In phase I trials for ADHD, test subjects reported the following side effects:

  • Loss of appetite
  • Dehydration
  • Cottonmouth
  • Nausea
  • Insomnia
  • Anxiety
  • Panic attacks
  • Headaches
  • References

    Dasotraline Wikipedia


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