Darke is a surname. Notable people with the surname include:
Francis Nicholson Darke (1863-1940), Leading citizen of Regina, Saskatchewan, Canada
Harold Darke (1888-1976), English composer and organist
Ian Darke, English football and boxing commentator
Jack Darke (c.1852–1897), British-born miller who spent his later life in the town of Gold Rush in Queensland, Australia
John Charles Darke (1806–1844), Surveyor and explorer in Van Diemen's Land (now Tasmania ) and South Australia
Nick Darke (1948-2005), British playwright
General William Darke (1736–1801), American soldier
William Wedge Darke (1810–1890), Australian colonist and surveyor
Fictional characters:
Sebastian Darke, eponymous hero of a series of children's novels written by British author Philip Caveney
