Entrez 80824 | Ensembl n/a | |
Aliases DUSP16, MKP-7, MKP7, dual specificity phosphatase 16 External IDs MGI: 1917936 HomoloGene: 15604 GeneCards: DUSP16 |
Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene.
The activation of mitogen-activated protein kinase (MAPK) cascades transduces various extracellular signals to the nucleus to induce gene expression, cell proliferation, differentiation, cell cycle arrest, and apoptosis. For full activation of MAPKs, dual-specificity kinases phosphorylate both threonine and tyrosine residues in MAPK TXY motifs. MKPs are dual-specificity phosphatases that dephosphorylate the TXY motif, thereby negatively regulating MAPK activity.[supplied by OMIM]
References
DUSP16 Wikipedia(Text) CC BY-SA