Species Human Entrez 1806 | Human Mouse Ensembl ENSG00000188641 | |
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Aliases DPYD, DHP, DHPDHASE, DPD, dihydropyrimidine dehydrogenase External IDs MGI: 2139667 HomoloGene: 85 GeneCards: DPYD | ||
Dihydropyrimidine dehydrogenase [NADP+] is an enzyme that in humans is encoded by the DPYD gene.
The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Genetic deficiency of this enzyme results in an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy.
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.
References
DPYD Wikipedia(Text) CC BY-SA