Trisha Shetty (Editor)

DOV 216,303

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Covid-19
CAS Number  410074-75-8
ChemSpider  7971043
Formula  C11H11Cl2N
PubChem CID  9795276
ChEMBL  CHEMBL528995
Molar mass  228.117 g/mol
DOV-216,303 httpsuploadwikimediaorgwikipediacommonsthu
Legal status  US: Investigational New Drug

DOV 216,303 is an antidepressant drug originally developed by DOV Pharmaceutical and was licensed to Merck & Co. in 2004; Merck and Dov terminated their relationship in December 2006.

It is a triple reuptake inhibitor (TRI), or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). It is the racemic mixture of amitifadine (DOV-21,947) and its (–)-enantiomer, DOV-102,677. Its IC50 values for SERT, NET, and DAT are Ki 14 nM, 20 nM, and 78 nM, respectively.

As of March 2008, Dov had no intention to further develop DOV-216,303 because the patent on the compound had expired.

References

DOV-216,303 Wikipedia


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