Entrez 84444 | Ensembl ENSG00000104885 | |
![]() | ||
External IDs MGI: 2143886 HomoloGene: 32779 GeneCards: DOT1L |
DOT1-like (Disruptor of telomeric silencing 1-like), histone H3K79 methyltransferase (S. cerevisiae), also known as DOT1L, is a protein found in humans, as well as other eukaryotes. The methylation of histone H3 lysine 79 (H3K79) by DOT1L which is a conserved epigenetic mark in many eukaryotic epigenomes, increases progressively along the aging process, suggesting that "DOT1L might function as a vital clock, ticking the hours impassively".
DOT1L has been reported to play an important role in the processes of mixed-lineage leukemia (MLL)-rearranged leukemias
Small molecule inhibitors of Dot1L catalytic activity have been developed.
References
DOT1L Wikipedia(Text) CC BY-SA