DNA ligase (NAD )

DNA ligase (NAD+) (EC 6.5.1.2, polydeoxyribonucleotide synthase (NAD⁺), polynucleotide ligase (NAD⁺), DNA repair enzyme, DNA joinase, polynucleotide synthetase (nicotinamide adenine dinucleotide), deoxyribonucleic-joining enzyme, deoxyribonucleic ligase, deoxyribonucleic repair enzyme, deoxyribonucleic joinase, DNA ligase, deoxyribonucleate ligase, polynucleotide ligase, deoxyribonucleic acid ligase, polynucleotide synthetase, deoxyribonucleic acid joinase, DNA-joining enzyme, polynucleotide ligase (nicotinamide adenine dinucleotide)) is an enzyme with systematic name poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming). This enzyme catalyses the following chemical reaction

NAD⁺ + (deoxyribonucleotide)_n + (deoxyribonucleotide)_m ⇌ AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)_n+m

Catalyses the formation of a phosphodiester at the site of a single-strand break in duplex DNA.